THE USE OF CRISPR IN TREATING GENETIC DISORDERS: PROMISE, PROGRESS, AND PRECISION
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Abstract
CRISPR-Cas9 genome editing technology has revolutionized molecular medicine, offering a highly precise, efficient, and cost-effective method for correcting genetic mutations. This article explores the therapeutic potential of CRISPR in treating monogenic and complex genetic disorders, including sickle cell disease, cystic fibrosis, Duchenne muscular dystrophy, and hereditary blindness. We review the current state of clinical trials, technical advancements, delivery mechanisms, and address bioethical and regulatory challenges. The review also highlights emerging strategies such as base editing, prime editing, and epigenome editing that are poised to enhance safety and broaden therapeutic applications
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